Diagnostic et traitement modernes des maladies de l'enfant; un traité sur les maladies médicales et chirurgicales de l'enfance anf . Fig. 144.—Pseudoleukemia Infantum Splenica. Notez la position de la rate agrandie. (Sheffield.) règle, il est observé en relation avec des formes prononcées de mal-nutrition, en particulier rachitis. Les principales altérations dans le sang sont la réduction de l'hémoglobine de sable rouge, la présence de nombreux corpuscules rouges nucléés et une augmentation du nombre de leucocytes, principalement du type mono-nucléaire. Cette image de sang correspond essentiellement au thétode l'anémie secondaire ordinaire. Po

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Modern diagnosis and treatment of diseases of childern; a treatise on the medical and surgical diseases of infancy anf childhood . Fig. 144.—Pseudoleukemia Infantum Splenica. Note positionof enlarged spleen. (Sheffield.) rule, it is observed in connection with pronounced forms of mal-nutrition, especially rachitis. The chief alterations in the blood are reduction of red cellsand hemoglobin, the presence of many nucleated red corpuscles, and an increase in the number of leucocytes, mostly of the mono-nuclear type. This blood picture essentially corresponds to thatof ordinary secondary anemia. In pseudoleukemia infantum. Increasedleucocytosis. 474 DISEASES OF BLOOD AXD DUCTLESS GLANDS. Enlarged however, there is marked enlargement of the spleen and occasion-spleen. ° ally also of the liver and lymphatic glands. The general symptoms differ but little from those observed insevere anemia. The same applies to the treatment. The syrupof the iodid of iron with the syrup of the hypophosphites seemto exert a specific action in the majority of cases.. Fig. 145.—Same case as Fig. 144 after three months tonic treat-ment. Note reduction in size of spleen. (Sheffield.) LEUKEMIA(Leucocythemia). _, . As the term indicates, leukemia is characterized principally High leuco- r cytosis with by an abnormal increase in the number of leucoevtes (sometimes unusual J J v biood-ceiisf reacning as high as a million), and by the presence of unusualtypes of these cells, i.e., Markzellen (myelocytes), Mastzellen(nutritive cells), and giant basophiles. From a pathologic point Splenic. PERNICIOUS ANEMIA. 475 of view it is customary to distinguish two forms of leukemia: Lymphatic.1. Lymphatic leukemia, in which the lymphatic glands are chieflyinvolved (hyperplasia), and 2. Splenomedullary or myelogenicform, in which the spleen (greatly increased in size) and thebone marrow (hyperplasia) are the principal seats of the lesion.Mixed forms also are encountered. The . principal difference ^-ms.betwee

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