Gynécologie pour les étudiants et les praticiens . Le liquide produit est appelé liquorfolliculi. Bien que formé à l'origine de la manière décrite, il isheld par certaines autorités d'être en partie une transsudation du vesselsof la thèque interne. Il s'agit d'un mince, contenant du liquide séreux albumen.follicules, tels que ceux-ci, sont présents en grand nombre après la puberté.Le plus grand nombre restent en dormance, mais certains d'entre eux l'objet d'afurther processus de maturation, se terminant en rupture, et sur thisdepends l'importante fonction de l'ovulation. Follicules matures areseldom pubertj a trouvé qu'après- : certainement pas de corpora

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Gynaecology for students and practitioners . The fluid produced is called liquorfolliculi. Although originally formed in the manner described, it isheld by some authorities to be partly a transudation from the vesselsof the theca interna. It is a thin, serous fluid containing albumen.Follicles, such as these, are present in large numbers after puberty.The greater number remain dormant, but some of them undergo afurther process of maturation, ending in rupture, and upon thisdepends the important function of ovulation. Mature follicles areseldom found until after pubertj- : certainly no corpora lutea haveever been found before this age. It follows from what has been saidthat only in the adult ovary are all three kinds of follicles to beobserved. 42 GYNECOLOGY As a rule, a single Graafian follicle ripens in one ovary at intervalsof about four weeks. It is at present uncertain whether this processcoincides with menstruation or not, but the physiological bearingswill be again referred to in connection with the theories of menstrua-. FiG. 30. EipeninCt Graafian Follicle (Stevens). An early stage showing the formation of the liquor folUculi by liquefaction of the membrana granulosa- cells. The egg-cell has greatly increased in size, and the zona pellucida has developed around it. tion. Occasionally two follicles ripen simultaneously, either in thesame or it may be, one in each ovary. The Mature Follicle. Starting with the dormant follicle the detailsof the ripening process are as follows : The central or egg-cell increasesin size, and a uniform strong capsule, showing fine radial striation, calledthe zona pellucida, is developed around it {see Figs. 29 and 30). Thezona pellucida is divided from the protoplasm of the egg-c&ll by theperivitelline space, in which the egg is free to move. The originallycentral nucleus is now pushed more and more towards the surfaceof the ovum by the development of its cytoplasm. The nucleolusis said to show amseboid movement. The cells derived

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