. Le bulletin biologique. Biologie ; zoologie ; biologie ; biologie marine. La STRUCTURE DE LA MEMBRANE CELLULAIRE ainsi que les substances dissoutes, dont la taille des molécules est suffisamment petit, peut passer à travers. Quant à la nature de la structure des membranes perméables aux cations-, que nous allons maintenant discuter, l'avis n'est pas encore suffisamment étayé. Tableau IV des potentiels de repos du nerf sciatique potentiel Temps Temps Solution Solution potentielle millivolts millii'cits 3:21:20 Ringer 3 20,6 27,4 20,5 3:53 Sonnerie Sonnerie 3:52:55 27,5 3 Sonnerie Sonnerie avec 0,08  % KC1 3:54 0,08 % avec sonnerie KC1  + 0,1 %du CaCl2 4 03:19

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. The Biological bulletin. Biology; Zoology; Biology; Marine Biology. STRUCTURE OF THE PLASMA MEMBRANE as well as dissolved substances, whose molecular size is small enough, can pass through. As to the character of the structure of the cation- permeable membranes, which we will now discuss, the opinion is not yet substantiated enough. TABLE IV Resting Potentials of the Sciatic Nerve Time Potential Solution Time Potential Solution millivolts millii'ctis 3:21 20.6 Ringer 3:20 27 .4 Ringer 3:53 20.5 Ringer 3:52 27.5 Ringer 3:55 Ringer with 0.08 % KC1 3:54 Ringer with 0.08% KC1 + 0.1%CaCl2 4:03 19.0 4:02 27.7 ( i 4:28 17.2 4:27 28.5 i ( 5:18 16.5 5:17 28.6 1 1 It seems that the cation-permeable membranes exist more fre- quently than anion-permeable membranes. As Bernstein and I have pointed out twenty-five years ago, the hypothesis of selective cation- permeability gives a good explanation of the electro-negativity that results from injury and of negativity resulting from activity. But if we produce a difference of potential in uninjured tissues such as muscles, liver and apple by joining their surfaces at two different points with two different salt solutions, then we see that, although the cations are better enabled to produce an electric current (ap- parently in connection with the negative character of the membrane colloids), the anions have an action too, the strength of which is correlated with their position in the lyotropic series: sulfate, chlorine, bromine, nitrate, iodine, thiocyanate. But the cations also do not act exactly according to the series of the size of the ions: csesium, rubidium, potassium, sodium, lithium, but succeed each other as potassium, rubidium, csesium, sodium, lithium, —a series met with rather often, as I have found in relation to changing the hydrophilic colloidal state, and characterized by the peculiar dislocation of caesium. And finally, regarding the membrane potentials of muscle and nerve, we encounter a cation antagonism, for ex

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