Les maladies endémiques des états du sud . Dr W. H. Harris.) grandes quantités de singes (Macacus rhesus). Le premier de ces animaux est resté apparemment normal pour beaucoup de monthsquand il a développé des taches noires irrégulières sur les mains, les bras de devant, le visage, le dos et les côtés du corps. Il s'est progressivement bécameemacié et faible et est finalement mort avec tous les signes de pellagra. Le deuxième singe après une période d'environ trois monthsdéveloppés lésions semblables au singe i, et au moment de la pub-lication était toujours vivant, bien que la croissance s'affaiblit progressivement et plus mince. Stimulée par ce travail de Harris, Lavinde

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The endemic diseases of the southern states . Dr. W. H. Harris.) large quantities into monkeys (Macacus rhesus). The firstof these animals remained apparently normal for many monthswhen he developed irregular dark patches on the hands, fore-arms, face, back and sides of the body. He gradually becameemaciated and weak and finally died with all the signs ofpellagra. The second monkey after a period of about three monthsdeveloped similar lesions to monkey i, and at the time of pub-lication was still living, though growing progressively weakerand thinner. Stimulated by this work of Harris, Lavinder, Francis, Grimmand Lorenz^^^ attacked the problem anew and by 103 experi-ments with 77 rhesus monkeys, 2 Java monkeys and 3 femalebaboons administered pellagrous material from every conceiv- 3IO ENDEMIC DISEASES OF THE SOUTHERN STATES able source and in every conceivable manner. The pellagrousmaterial consisted of tissue extracts, pericardial and spinalfluids from necropsies, and blood, urine, feces and spinalfluid collected during life. f. Fig. 6g.—Monke> shoMn_; liMon, o( hands and face.Dr W . H Harris.) (Courtesy of The inoculations were made intravenously, intraperitoneally, intraspinally and material was fed by stomach tube. Eight of the animals died after varying periods followinginoculation. Four of them showed plainly death was not dueto pellagra. The cause of death was not determined in theother four. The remaining monkeys with one exception had up to the time PELLAGRA 3II of the publication of the report shown no indications suggestingpellagra. The following is the history of the exception: M. Rhesus, 98, was injected intraspinally with 6 c.c. of spinalfluid, April 14, 1914, and again inoculated, May 2, intraspinallywith 4 c.c. of spinal fluid drawn from another pellagrin. Thefirst change in this monkey was noted May 4, 1914, at whichtime the right forearm appeared slightly swollen and lookedas though some of the hair was falling out. The followingday the left

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