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Edward David Freis (1912-2005) was an American cardiologist who made key contributions to clinical and scientific understanding of cardiovascular disease. He is best known as the father of the first double-blind, multi-institutional controlled clinical trial of cardiovascular drugs, the Veterans Administration Cooperative Study on Antihypertensive Agents. This landmark study demonstrated that treating high blood pressure--hypertension--with medication could dramatically reduce disability and death from stroke, congestive heart failure, and other cardiovascular diseases. Freis received a Lasker Award in 1971 in recognition of this work. The study provided the impetus for the establishment of the National High Blood Pressure Education Program by the National Heart, Lung, and Blood Institute in 1972, and launched an era of preventive cardiology.