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Transmission electron micrograph (TEM) revealed some of the internal cross-sectional structural morphology of a rabies virion (arrow) in this central nervous system tissue specimen. The virion is adjacent to a Negri body, which is pathognomonic in the positive diagnosis for Rabies. The virus infects the central nervous system, causing encephalopathy and ultimately death. Rabies virus belongs to the order Mononegavirales, viruses with a nonsegmented, negative-sense single-stranded RNA ((-) ssRNA) genomes. Early symptoms of rabies in humans are nonspecific, consisting of fever, headache, and general malaise. As the disease progresses, neurological symptoms appear and may include insomnia, anxiety, confusion, slight or partial paralysis, excitation, hallucinations, agitation, hyper-salivation, difficulty swallowing, and hydrophobia (fear of water). Death usually occurs within days of the onset of symptoms.
